Adaptive stimulus selection methods in neuroscience have primarily focused on maximizing the firing rate of a single recorded neuron.

Modeling neural population dynamics underlying noisy single-trial spiking activities is essential for relating neural observation and behavior.

Adaptive stimulus selection methods in neuroscience have primarily focused on maximizing the firing rate of a single recorded neuron. When recording from a population of neurons, it is usually not possible to find a single stimulus that maximizes the firing rates of all neurons. This motivates optimizing an objective function that takes into account the responses of all recorded neurons together. We propose "Adept," an adaptive stimulus selection method that can optimize population objective functions. In simulations, we first confirmed that population objective functions elicited more diverse stimulus responses than single-neuron objective functions. Then, we tested Adept in a closed-loop electrophysiological experiment in which population activity was recorded from macaque V4, a cortical area known for mid-level visual processing. To predict neural responses, we used the outputs of a deep convolutional neural network model as feature embeddings. Natural images chosen by Adept elicited mean neural responses that were 20% larger than those for randomly-chosen natural images, and also evoked a larger diversity of neural responses. Such adaptive stimulus selection methods can facilitate experiments that involve neurons far from the sensory periphery, for which it is often unclear which stimuli to present.

We present a novel non-parametric method for finding a subspace of stimulus features that contains all information about the response of a system. Our method generalizes similar approaches to this problem such as spike triggered average, spike triggered covariance, or maximally informative dimensions. Instead of maximizing the mutual information between features and responses directly, we use integral probability metrics in kernel Hilbert spaces to minimize the information between uninformative features and the combination of informative features and responses. Since estimators of these metrics access the data via kernels, are easy to compute, and exhibit good theoretical convergence properties, our method can easily be generalized to populations of neurons or spike patterns. By using a particular expansion of the mutual information, we can show that the informative features must contain all information if we can make the uninformative features independent of the rest.

How the human vision system addresses the object identity-preserving recognition problem is largely unknown. Here, we use a vision recognition-reconstruction network (RRN) to investigate the development, recognition, learning and forgetting mechanisms, and achieve similar characteristics to electrophysiological measurements in monkeys. First, in network development study, the RRN also experiences critical developmental stages characterized by specificities in neuron types, synapse and activation patterns, and visual task performance from the early stage of coarse salience map recognition to mature stage of fine structure recognition. In digit recognition study, we witness that the RRN could maintain object invariance representation under various viewing conditions by coordinated adjustment of responses of population neurons. And such concerted population responses contained untangled object identity and properties information that could be accurately extracted via high-level cortices or even a simple weighted summation decoder. In the learning and forgetting study, novel structure recognition is implemented by adjusting entire synapses in low magnitude while pattern specificities of original synaptic connectivity are preserved, which guaranteed a learning process without disrupting the existing functionalities. This work benefits the understanding of the human visual processing mechanism and the development of human-like machine intelligence.

Adaptive stimulus selection methods in neuroscience have primarily focused on maximizing the firing rate of a single recorded neuron. When recording from a population of neurons, it is usually not possible to find a single stimulus that maximizes the firing rates of all neurons. This motivates optimizing an objective function that takes into account the responses of all recorded neurons together. We propose “Adept,” an adaptive stimulus selection method that can optimize population objective functions. In simulations, we first confirmed that population objective functions elicited more diverse stimulus responses than single-neuron objective functions. Then, we tested Adept in a closed-loop electrophysiological experiment in which population activity was recorded from macaque V4, a cortical area known for mid-level visual processing. To predict neural responses, we used the outputs of a deep convolutional neural network model as feature embeddings. Images chosen by Adept elicited mean neural responses that were 20% larger than those for randomly-chosen natural images, and also evoked a larger diversity of neural responses. Such adaptive stimulus selection methods can facilitate experiments that involve neurons far from the sensory periphery, for which it is often unclear which stimuli to present.